Education:
Bowdoin College
Biochemistry major, Music minor
B.A., 2014
University of Minnesota - Twin Cities
Microbiology, Immunology and Cancer Biology Graduate Program
Ph.D., 2023
Honors and Awards
- Ruth L. Kirschstein National Research Service Award for Predoctoral MD/PhD Fellows, National Cancer Institute, 2020-2024
MSTP Student Governance:
- Student Advisory Committee 2018-2020 (co-chair 2018-2019; chair 2019-2020)
Thesis Advisor: David Masopust, Ph.D.
Thesis Research
Adaptive immunity, expanding our understanding and potential utilization of tissue-resident memory T-cells in multiple contexts from infectious disease to cancer.
Publications (pubmed)
Stolley JM, Scott MC, Joag V, Dale AJ, Johnston TS, Saavedra F, Gavil NV, Lotfi-Emran S, Soerens AG, Weyu E, Pierson MJ, Herzberg MC, Zhang N, Vezys V, Masopust D. Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa. J Exp Med. 2023 Jul 3;220(7):e20221853. PMCID: PMC10130744
Gavil NV, Scott MC, Weyu E, Smith OC, O'Flanagan SD, Wijeyesinghe S, Lotfi-Emran S, Shiao SL, Vezys V, Masopust D. Chronic antigen in solid tumors drives a distinct program of T cell residence. Sci Immunol. 2023 Jun 8;8(84):eadd5976. PMCID: PMC10569081
Jarjour NN, Wanhainen KM, Peng C, Gavil NV, Maurice NJ, Borges da Silva H, Martinez RJ, Dalzell TS, Huggins MA, Masopust D, Hamilton SE, Jameson SC. Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8+ T cell subsets. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209021119. PMCID: PMC9618124
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. Functional virus-specific memory T cells survey glioblastoma. Cancer Immunol Immunother. 2022 Aug;71(8):1863-1875. PMCID: PMC9271132
Wang H, Gavil NV, Koewler N, Masopust D, Jameson SC. Parabiosis in Mice to Study Tissue Residency of Immune Cells. Curr Protoc. 2022 May;2(5):e446. PMCID: PMC9216177
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. Correction to: Functional virus specific memory T cells survey glioblastoma. Cancer Immunol Immunother. 2022 Feb 18.
Ning J, Gavil NV, Wu S, Wijeyesinghe S, Weyu E, Ma J, Li M, Grigore FN, Dhawan S, Skorput AGJ, Musial SC, Chen CC, Masopust D, Rosato PC. Functional virus-specific memory T cells survey glioblastoma. Cancer Immunol Immunother. 2022 Jan 10.
Joag V, Wijeyesinghe S, Stolley JM, Quarnstrom CF, Dileepan T, Soerens AG, Sangala JA, O'Flanagan SD, Gavil NV, Hong SW, Bhela S, Gangadhara S, Weyu E, Matchett WE, Thiede J, Krishna V, Cheeran MC, Bold TD, Amara R, Southern P, Hart GT, Schifanella L, Vezys V, Jenkins MK, Langlois RA, Masopust D. Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses. J Immunol. 2021 Mar 1;206(5):931-935. PMCID: PMC8136468
Work prior to the UMN MSTP:
Stetler-Stevenson WG, Gavil NV. Normalization of the tumor microenvironment: evidence for tissue inhibitor of metalloproteinase-2 as a cancer therapeutic. Connect Tissue Res. 2014 Jan-Feb;55(1):13-9. Review.
Bourboulia D, Han H, Jensen-Taubman S, Gavil N, Isaac B, Wei B, Neckers L, Stetler-Stevenson WG. TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells. Oncotarget. 2013 Jan 27;4(1):163-73. PMCID: PMC3702216
