John R. Lozada

Grad Program
Class of
2021


Education: 
University of Rochester
Molecular Genetics major, Business minor
B.S., 2021

MSTP Student Governance:

  • Student Advisory Committee, 2021-23
  • Student Admissions and Recruitment Committee, 2023-24
  • Justice, Equity, Diversity and Inclusion Committee, 2022-24

Thesis Advisor: Frank Cichocki, Ph.D.

Publications:

Bergom HE, Sena LA, Day A, Miller B, Miller CD, Lozada JR, Zorko N, Wang J, Shenderov E, Lobo FP, Caramella-Pereira F, Marchionni L, Drake CG, Lotan T, De Marzo AM, Hwang J, Antonarakis ES. Divergent immune microenvironments in two tumor nodules from a patient with mismatch repair-deficient prostate cancer. NPJ Genom Med. 2024 Jan 22;9(1):7. PMCID: PMC10803790

Lozada JR, Zhang B, Miller JS, Cichocki F. NK Cells from Human Cytomegalovirus-Seropositive Individuals Have a Distinct Metabolic Profile That Correlates with Elevated mTOR Signaling. J Immunol. 2023 Aug 15;211(4):539-550.

Hwang J, Shi X, Elliott A, Arnoff TE, McGrath J, Xiu J, Walker P, Bergom HE, Day A, Ahmed S, Tape S, Makovec A, Ali A, Shaker RM, Toye E, Passow R, Lozada JR, Wang J, Lou E, Mouw KW, Carneiro BA, Heath EI, McKay RR, Korn WM, Nabhan C, Ryan CJ, Antonarakis ES. Clin Cancer Res. Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes. 2023 Jul 14;29(14):2702-2713.

Bergom HE, Shabaneh A, Day A, Ali A, Boytim E, Tape S, Lozada JR, Shi X, Kerkvliet CP, McSweeney S, Pitzen SP, Ludwig M, Antonarakis ES, Drake JM, Dehm SM, Ryan CJ, Wang J, Hwang J. ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems. Commun Biol. 2023 Apr 14;6(1):417. PMCID: PMC10104859

For work prior to the UMN MSTP:

Beca F, Sebastiao APM, Pareja F, Dessources K, Lozada JR, Geyer F, Selenica P, Zeizafoun N, Wen HY, Norton L, Brogi E, Weigelt B, Reis-Filho JS. Whole-exome analysis of metaplastic breast carcinomas with extensive osseous differentiation. Histopathology. 2020 Aug;77(2):321-326.

Xu B, Barbieri AL, Bishop JA, Chiosea SI, Dogan S, Di Palma S, Faquin WC, Ghossein R, Hyrcza M, Jo VY, Lewis JS Jr, Lozada JR, Michal M, Pareja FG, Perez-Ordonez B, Prasad ML, Purgina B, Reis-Filho JS, Scognamiglio T, Sebastiao APM, Seethala RR, Skálová A, Smith SM, Tekkeşin MS, Thompson LDR, Wasseman JK, Wenig BM, Weinreb I, Katabi N. Histologic Classification and Molecular Signature of Polymorphous Adenocarcinoma (PAC) and Cribriform Adenocarcinoma of Salivary Gland (CASG): An International Interobserver Study. Am J Surg Pathol. 2020 Apr;44(4):545-552. PMCID: PMC7437128

Pareja F, da Silva EM, Frosina D, Geyer FC, Lozada JR, Basili T, Da Cruz Paula A, Zhong E, Derakhshan F, D'Alfonso T, Wen HY, Giri DD, Hayes MM, Krings G, Bhargava R, Palazzo JP, Rakha EA, Hoda SA, Sanders ME, Collins LC, Schnitt SJ, Chen YY, Weigelt B, Jungbluth AA, Reis-Filho JS, Brogi E. Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity. Mod Pathol. 2020 Jun;33(6):1056-1064. PMCID: PMC7286791

Sebastiao APM, Xu B, Lozada JR, Pareja F, Geyer FC, Da Cruz Paula A, da Silva EM, Ghossein RA, Weinreb I, de Noronha L, Weigelt B, Reis-Filho JS, Katabi N. Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes. Mod Pathol. 2020 Jan;33(1):65-73. PMCID: PMC6930326

Li A, Geyer FC, Blecua P, Lee JY, Selenica P, Brown DN, Pareja F, Lee SSK, Kumar R, Rivera B, Bi R, Piscuoglio S, Wen HY, Lozada JR, Gularte-Mérida R, Cavallone L; kConFab Investigators, Rezoug Z, Nguyen-Dumont T, Peterlongo P, Tondini C, Terkelsen T, Rønlund K, Boonen SE, Mannerma A, Winqvist R, Janatova M, Rajadurai P, Xia B, Norton L, Robson ME, Ng PS, Looi LM, Southey MC, Weigelt B, Soo-Hwang T, Tischkowitz M, Foulkes WD, Reis-Filho JS. Homologous recombination DNA repair defects in PALB2-associated breast cancers. NPJ Breast Cancer. 2019 Nov 19;5:44. PMCID: PMC6864058

Lozada JR, Geyer FC, Selenica P, Brown D, Alemar B, Merghoub T, Berger MF, Busam KJ, Halpern AC, Weigelt B, Reis-Filho JS, Hollmann TJ. Massively parallel sequencing analysis of benign melanocytic naevi. Histopathology. 2019 Jul;75(1):29-38. PMCID:PMC6752735

Pareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, Da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, Alemar B, Bi R, Lim RS, de Bruijn I, Fujisawa S, Gardner R, Feng E, Li A, da Silva EM, Lozada JR, Blecua P, Cohen-Gould L, Jungbluth AA, Rakha EA, Ellis IO, Edelweiss MIA, Palazzo J, Norton L, Hollmann T, Edelweiss M, Rubin BP, Weigelt B, Reis-Filho JS. Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors. Nat Commun. 2018 Aug 30;9(1):3533. PMCID: PMC6117336

Lozada JR, Basili T, Pareja F, Alemar B, Paula ADC, Gularte-Merida R, Giri DD, Querzoli P, Cserni G, Rakha EA, Foschini MP, Reis-Filho JS, Brogi E, Weigelt B, Geyer FC. Solid papillary breast carcinomas resembling the tall cell variant of papillary thyroid neoplasms (solid papillary carcinomas with reverse polarity) harbour recurrent mutations affecting IDH2 and PIK3CA: a validation cohort. Histopathology. 2018 Aug;73(2):339-344. PMCID: PMC6783257

Geyer FC, Li A, Papanastasiou AD, Smith A, Selenica P, Burke KA, Edelweiss M, Wen HC, Piscuoglio S, Schultheis AM, Martelotto LG, Pareja F, Kumar R, Brandes A, Fan D, Basili T, Da Cruz Paula A, Lozada JR, Blecua P, Muenst S, Jungbluth AA, Foschini MP, Wen HY, Brogi E, Palazzo J, Rubin BP, Ng CKY, Norton L, Varga Z, Ellis IO, Rakha EA, Chandarlapaty S, Weigelt B, Reis-Filho JS. Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas. Nat Commun. 2018 May 8;9(1):1816. PMCID: PMC5940840

Lozada JR, Burke KA, Maguire A, Pareja F, Lim RS, Kim J, Gularte-Merida R, Murray MP, Brogi E, Weigelt B, Reis-Filho JS, Geyer FC. Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study. Histopathology. 2017 Oct;71(4):626-634. PMCID: PMC5597459

John R.